Assuntos
Doenças dos Nervos Cranianos/etiologia , Doenças Orbitárias/etiologia , Sinusite/microbiologia , Infecções Estafilocócicas/microbiologia , Antibacterianos/uso terapêutico , Doenças dos Nervos Cranianos/diagnóstico , Doenças dos Nervos Cranianos/tratamento farmacológico , Dexametasona/uso terapêutico , Diplopia/diagnóstico , Floxacilina/uso terapêutico , Glucocorticoides/uso terapêutico , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Doenças Orbitárias/diagnóstico , Doenças Orbitárias/tratamento farmacológico , Sinusite/diagnóstico por imagem , Sinusite/tratamento farmacológico , Infecções Estafilocócicas/diagnóstico por imagem , Infecções Estafilocócicas/tratamento farmacológico , Síndrome , Tomografia Computadorizada por Raios X , Transtornos da Visão/diagnósticoAssuntos
Disco Óptico/patologia , Papiledema/etiologia , Doença de Whipple/complicações , Administração Oral , Antibacterianos/uso terapêutico , Ceftriaxona/uso terapêutico , Quimioterapia Combinada , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Papiledema/diagnóstico , Papiledema/tratamento farmacológico , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Tropheryma/isolamento & purificação , Doença de Whipple/tratamento farmacológico , Doença de Whipple/microbiologiaRESUMO
AIM: We aim (i) to characterise the clinical features of vitamin A deficiency (VAD) in a small cohort of Australian children; (ii) to determine the effects of VAD; and (iii) to quantify the prevalence of ophthalmic review in this group. METHODS: Data collected from the charts incorporated patient demographics, laboratory results, past medical history, ophthalmic symptoms and dietary history. Outcome measures were (i) occurrence of VAD in our study population; (ii) presence of associated systemic effects and ocular manifestations in those diagnosed with VAD; and (iii) determination of whether children with VAD had an ophthalmology review. RESULTS: Fifty-two of the 146 children had VAD; their average age was 8.4 years (range 11 days to 18 years old). In this Australian cohort, the most common pre-existing medical conditions in those children whose vitamin A status was investigated were cystic fibrosis, gastro-oesophageal reflux disease, micronutrient deficiency and short gut syndrome. The most common medical conditions affecting children with measured VAD in this cohort include autism, coeliac disease and cystic fibrosis. A significant association was found between VAD and anaemia and serum iron levels. Of the 146 children, 28 had ophthalmology review, of whom 13 had VAD. The most common reason for ophthalmology review was retinopathy of prematurity; there was only one referral for review for xerophthalmia. There was one case of xerophthalmia referred due to microbial keratitis. CONCLUSION: Vitamin A deficiency and xerophthalmia do exist in children of developed country. The potential for xerophthalmia should be considered, and there should be a consideration of an ophthalmology review.
Assuntos
Deficiência de Vitamina A/epidemiologia , Deficiência de Vitamina A/fisiopatologia , Xeroftalmia/epidemiologia , Xeroftalmia/fisiopatologia , Adolescente , Austrália/epidemiologia , Criança , Pré-Escolar , Bases de Dados Factuais , Feminino , Humanos , Lactente , Masculino , Estudos RetrospectivosRESUMO
We report the ocular and systemic manifestations of vitamin A deficiency in a child with a complicated medical history including autism and a restricted diet, living in a developed country. This child had significant vitamin A deficiency despite being under long-term medical care, yet the diagnosis was not considered until he had an ophthalmology review for visual deterioration.
